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Ubiquitin—a beacon for all during quality control on the ribosome
Author(s) -
Yan Liewei L,
Zaher Hani S
Publication year - 2019
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2019101633
Subject(s) - biology , ribosome , ubiquitin , microbiology and biotechnology , genetics , computational biology , rna , gene
Ribosome stalling triggers no‐go decay ( NGD ) and ribosome‐associated quality control ( RQC ) pathways to rapidly degrade the aberrant mRNA and the incomplete nascent peptide, respectively. Two recent studies in yeast and mammalian systems reveal the importance of stalling‐induced ribosomal protein ubiquitination by Hel2/ ZNF 598 for both NGD and RQC . The studies also structurally explain how collided ribosomes generate a unique interface not present in monosomes, which can be recognized by Hel2/ ZNF 598 ubiquitin ligases.