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How DNA vicinity controls SUMO E3 ligase activity
Author(s) -
Pichler Andrea
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201899705
Subject(s) - biology , epigenetics , dna ligase , dna replication , genetics , dna repair , dna methylation , dna , dna ligases , microbiology and biotechnology , ubiquitin ligase , ubiquitin , gene , gene expression
Little is known about the regulation of SUMO E3 ligases and how they are activated upon stress. New findings from the Reverter and Torres‐Rosell laboratories in The EMBO Journal demonstrate that vicinity of preferentially ss DNA activates the SUMO E3 ligase Nse2 when in complex with SMC 5‐6.