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The Hfq chaperone helps the ribosome mature
Author(s) -
Sharma Indra Mani,
Korman Arthur,
Woodson Sarah A
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201899616
Subject(s) - ribosome , library science , biology , gerontology , genetics , medicine , computer science , rna , gene
Ribosome biogenesis is a complex process that is facilitated by a large number of assembly factors. In this issue, Andrade et al ([Andrade JM, 2018]) provide evidence that a widely conserved RNA chaperone, Hfq, acts as a ribosomal assembly factor in bacteria. Hfq is known to support regulation of stress response genes by small RNA s. Andrade et al ([Andrade JM, 2018]) show that the absence of Hfq results in higher levels of immature 30S ribosomes and error‐prone translation, suggesting that Hfq globally affects the quality of protein synthesis when bacteria are under stress.