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Anti‐cancer therapy: senescence is the new black
Author(s) -
Leite de Oliveira Rodrigo,
Bernards Rene
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201899386
Subject(s) - cancer , carcinogenesis , biology , cancer research , library science , genetics , computer science
Cellular senescence is a natural safeguard against cancer. Pharmacologically, it can be induced by drugs that inhibit the CDK 4/6 kinases such as palbociclib, but the exact mechanism has never been dissected. Recent research by Miettinen et al ([Miettinen TP, 2018]) reveals that senescence induced by this class of drugs is mediated by proteasome hyper‐activation.