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Waking up muscle stem cells: PI 3K signalling is ringing
Author(s) -
Relaix Frederic,
Machado Léo
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201899297
Subject(s) - humanities , medicine , library science , art , computer science
Adult skeletal muscle injury instructs endogenous quiescent stem cells to activate for repair. The pathways involved in this activation remain poorly understood. An elegant study by Wang et al ([Wang G, 2018]) combine mouse molecular genetics with muscle regeneration experiments, cell culture and transcriptomic analysis to show that early activation depends on a PI 3K‐ mTORC 1‐Jun/FoxOs signalling axis.