Premium
Metastasis inside‐out: dissemination of cancer cell clusters with inverted polarity
Author(s) -
Ewald Andrew J
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201899144
Subject(s) - metastasis , cancer , multicellular organism , biology , cancer cell , colorectal cancer , cancer research , library science , cell , computer science , genetics
Zajac et al ([Zajac O, 2018]) utilize patient tissue to discover a novel cellular mechanism for metastasis in colorectal cancer. They isolated cancer cell clusters from patient peritoneal fluid and demonstrated that these clusters invaded collectively into collagen gels, patient‐derived tissues, and through the peritoneum of mice. During invasion the clusters retained an inverted epithelial architecture, functioning as multicellular metastatic seeds with inverted polarity.