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No way out: when RNA elements promote nuclear retention
Author(s) -
Agostini Federico,
Ule Jernej,
Zagalak Julian A
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201899123
Subject(s) - biology , rna , microbiology and biotechnology , computational biology , genetics , gene
The proper localization of RNA transcripts is a highly controlled and fine‐tuned process. Indeed, regulation of RNA trafficking is mediated by both cis ‐acting elements and trans ‐acting factors, and defects in either mechanism have been associated with disease. Identifying the RNA sequence motifs that determine cellular localization for a given transcript therefore represents an important and challenging task. A new study from Shukla et al in The EMBO Journal —along with related work from Lubelsky and Ulitsky published elsewhere—describes a new screen that uses hybrid RNA s with barcoded oligonucleotides to identify cis ‐acting elements that increase the propensity of RNA s to be retained in the nuclear compartment.