STIM 1 (c) AMP s up melanogenesis

STIM 1 and STIM 2 are endoplasmic reticulum Ca 2+ sensors that serve multi‐faceted roles in signal transduction in a wide variety of different cell types. In this issue of  The EMBO Journal , Motiani et al define and characterize the ability of STIM 1 to control cAMP generation in a new context, melanin production (Motiani et al , [Motiani RK, 2018]), offering new insights into the physiological role of STIM 1.