Premium
Fat‐fated microglial dysfunction
Author(s) -
Silvin Aymeric,
Ginhoux Florent
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2018101176
Subject(s) - agency (philosophy) , china , sign (mathematics) , microglia , library science , immunology , biology , history , computer science , sociology , social science , mathematical analysis , mathematics , archaeology , inflammation
Patients with lysosomal storage disorders ( LSD s) exhibit activated microglia in the brain, but the mechanisms underlying microglial activation and contribution to disease pathology are unclear. In this issue, Gabandé‐Rodríguez et al present intriguing data to suggest a protective function for microglia that is corrupted by sphingolipid lysosomal overload in Niemann‐Pick disease type A.