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A magic bullet for targeting cancers with supernumerary centrosomes
Author(s) -
Liu Yi,
Pelletier Laurence
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2018101134
Subject(s) - magic bullet , cancer genetics , library science , notice , biology , genetics , cancer , political science , bioinformatics , law , computer science
Centrosome amplification is frequently observed in aggressive human cancers, and it has been proposed as a promising target in cancer therapy. Work by Mariappan et al ([Mariappan A, 2019]) in this issue details the identification of a small‐molecule inhibitor that perturbs the CPAP –tubulin interaction, prevents efficient centrosome clustering during mitosis, and exhibits in vivo anti‐tumor activity. This study demonstrates the potential of developing tumor‐specific treatment by specifically targeting centrosome amplification.