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More than just an IκB kinase: the IKK complex coordinates mRNA stability and transcription
Author(s) -
Perkins Neil D
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2018101084
Subject(s) - iκb kinase , transcription (linguistics) , transcription factor , kinase , messenger rna , newcastle upon tyne , biology , microbiology and biotechnology , genetics , gene , art , philosophy , linguistics , art history
The IκB kinase ( IKK ) complex is best known as the core regulator of NF ‐κB signalling. Recent work from Mikuda et al reveals a new and unexpected function for IKK in the regulation of mRNA stability. Through interacting with and phosphorylating EDC 4, a key component of the mRNA decapping complex, IKK regulates P‐body formation and the stability of numerous mRNA s, including many encoding inflammatory cytokines. Activation of IKK can therefore be more generally thought of as programming the cellular response to stress and infection through both mRNA stability and transcription.