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Friend and foe, HNRNPC takes on immunostimulatory RNA s in breast cancer cells
Author(s) -
Sarbanes Stephanie L,
Le Pen Jérémie,
Rice Charles M
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2018100923
Subject(s) - infectious disease (medical specialty) , breast cancer , library science , carcinogenesis , virology , cancer , disease , medicine , biology , genetics , computer science
The RNA ‐binding protein HNRNPC is highly expressed in breast cancer, but its contribution to tumorigenesis was unclear. In this issue, Wu et al ([Wu Y, 2018]) demonstrate that elevated HNRNPC is essential for the proliferative ability of two breast cancer cell lines. Reducing HNRNPC results in the accumulation of short Alu‐derived ds RNA s that bind RNA receptor RIG ‐I and stimulate the production of IFN , a cytokine with known antiproliferative activity.