Friend and foe,  HNRNPC  takes on immunostimulatory  RNA s in breast cancer cells | Zendy

Sarbanes Stephanie L | Zendy; Le Pen Jérémie | Zendy; Rice Charles M | Zendy

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Friend and foe, HNRNPC takes on immunostimulatory RNA s in breast cancer cells

Author(s) -

Sarbanes Stephanie L,

Le Pen Jérémie,

Rice Charles M

Publication year - 2018

Publication title -

the embo journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.484

H-Index - 392

eISSN - 1460-2075

pISSN - 0261-4189

DOI - 10.15252/embj.2018100923

Subject(s) - infectious disease (medical specialty) , breast cancer , library science , carcinogenesis , virology , cancer , disease , medicine , biology , genetics , computer science

The RNA ‐binding protein HNRNPC is highly expressed in breast cancer, but its contribution to tumorigenesis was unclear. In this issue, Wu et al ([Wu Y, 2018]) demonstrate that elevated HNRNPC is essential for the proliferative ability of two breast cancer cell lines. Reducing HNRNPC results in the accumulation of short Alu‐derived ds RNA s that bind RNA receptor RIG ‐I and stimulate the production of IFN , a cytokine with known antiproliferative activity.

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