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Decapping enzymes STOP “cancer” ribosomes in their tracks
Author(s) -
Mugridge Jeffrey S,
Gross John D
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2018100801
Subject(s) - ribosome , ribosome biogenesis , ribosomal rna , small nucleolar rna , rna processing , nucleolus , biology , rna , genetics , gene , non coding rna , cytoplasm
The production of ribosomes plays a central role in regulating cell cycle progression and cancer proliferation. A new study by Gaviraghi et al ([Gaviraghi M, 2018]) shows that mRNA decapping coactivator PNRC 1 acts as a tumor suppressor by regulating ribosome biogenesis. PNRC 1 relocalizes the Dcp1/Dcp2 mRNA decapping complex to the nucleolus and promotes decapping of specific sno RNA s to disrupt the processing of ribosomal RNA . By slowing rRNA processing, and thus ribosome biogenesis, PNRC 1 acts as a gatekeeper that restrains oncogenic potential.