Premium
Right time, right place— DNA damage and DNA replication checkpoints collectively safeguard S phase
Author(s) -
Galanti Lorenzo,
Pfander Boris
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2018100681
Subject(s) - biology , dna replication , dna , genome , dna damage , genetics , microbiology and biotechnology , gene
The DNA replication checkpoint ( DRC ) and the DNA damage checkpoint ( DDC ) are two closely linked signaling cascades that adjust S phase to the presence of DNA lesions and other replication impediments. Two recent studies published in The EMBO Journal shed new light on their relationship in budding yeast, collectively showing that the two pathways—while sharing several factors—differ in the location and kinetics of their activation, suggesting that they constitute different branches of an integrated cellular response to impaired DNA replication.