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ATF 4‐amino acid circuits: a recipe for resistance in melanoma
Author(s) -
Fernandez Mario R,
Cleveland John L
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2018100600
Subject(s) - cancer , library science , cancer cell , cancer research , biology , genetics , computer science
Lactate dehydrogenase A ( LDHA ) has appropriately received attention as a therapeutic target for the treatment of a broad spectrum of tumor types, yet little is known regarding intrinsic resistance to LDHA inhibitors. Pathria et al ([Pathria G, 2018]) now establish that ATF 4‐dependent control of enzymes that direct amino acid metabolism confers resistance to LDHA inhibitors in melanoma and identify chokepoints that can be exploited to overcome metabolic compensation, setting the stage for trials with such combinations.