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Choroid plexus‐derived miR‐204 regulates the number of quiescent neural stem cells in the adult brain
Author(s) -
Lepko Tjasa,
Pusch Melanie,
Müller Tamara,
Schulte Dorothea,
Ehses Janina,
Kiebler Michael,
Hasler Julia,
Huttner Hagen B,
Vandenbroucke Roosmarijn E,
Vandendriessche Charysse,
Modic Miha,
MartinVillalba Ana,
Zhao Sheng,
LLorensBobadilla Enric,
Schneider Anja,
Fischer Andre,
Breunig Christopher T,
Stricker Stefan H,
Götz Magdalena,
Ninkovic Jovica
Publication year - 2019
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2018100481
Subject(s) - biology , choroid plexus , neural stem cell , microrna , stem cell , microbiology and biotechnology , neuroscience , neurogenesis , anatomy , central nervous system , genetics , gene
Abstract Regulation of adult neural stem cell ( NSC ) number is critical for lifelong neurogenesis. Here, we identified a post‐transcriptional control mechanism, centered around the micro RNA 204 (miR‐204), to control the maintenance of quiescent (q) NSC s. miR‐204 regulates a spectrum of transcripts involved in cell cycle regulation, neuronal migration, and differentiation in qNSC s. Importantly, inhibition of miR‐204 function reduced the number of qNSC s in the subependymal zone ( SEZ ) by inducing pre‐mature activation and differentiation of NSC s without changing their neurogenic potential. Strikingly, we identified the choroid plexus of the mouse lateral ventricle as the major source of miR‐204 that is released into the cerebrospinal fluid to control number of NSC s within the SEZ . Taken together, our results describe a novel mechanism to maintain adult somatic stem cells by a niche‐specific mi RNA repressing activation and differentiation of stem cells.