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MIM through MOM : the awakening of Bax and Bak pores
Author(s) -
Cosentino Katia,
GarcíaSáez Ana J
Publication year - 2018
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.2018100340
Subject(s) - cytosol , biology , mitochondrion , apoptosis , microbiology and biotechnology , biochemistry , enzyme
The mechanism whereby mitochondrial DNA (mt DNA ) is released into the cytosol and activates the cGAS / STING inflammatory pathway during Bax/Bax‐mediated apoptosis is unknown. In this issue, Riley et al ([Riley JS, 2018]) report that widening of Bax and Bak pores on the mitochondrial outer membrane ( MOM ) during apoptosis allows the extrusion of the mitochondrial inner membrane ( MIM ) into the cytosol and its permeabilization to release mt DNA independently of caspases. In this scenario, Bax and Bak emerge as key modulators of the apoptotic immunogenic response.