Functional patchworking at the plasma membrane | Zendy

Léon Sébastien | Zendy; Teis David | Zendy

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Functional patchworking at the plasma membrane

Author(s) -

Léon Sébastien,

Teis David

Publication year - 2018

Publication title -

the embo journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.484

H-Index - 392

eISSN - 1460-2075

pISSN - 0261-4189

DOI - 10.15252/embj.2018100144

Subject(s) - biology , compartmentalization (fire protection) , transporter , microbiology and biotechnology , membrane , membrane transport protein , yeast , transport protein , membrane protein , saccharomyces cerevisiae , lipid microdomain , biochemistry , biophysics , enzyme , gene

Lipids and proteins are not evenly distributed within the plasma membrane ( PM ), but instead segregate laterally into many specialized microdomains whose functional relevance is not clear. In this issue, Busto et al ([Busto JV, 2018]) demonstrate that substrate flux through a nutrient transporter drives the lateral relocation of the transporter between specific microdomains at the yeast PM , suggesting that regulating the lateral plasma membrane compartmentalization for individual proteins could be a general process for cellular response to environmental conditions.

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