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Cohesin: building loops, but not compartments
Author(s) -
Haarhuis Judith HI,
Rowland Benjamin D
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201798654
Subject(s) - biology , cohesin , computational biology , microbiology and biotechnology , genetics , evolutionary biology , dna , chromatin
DNA is subjected to major cellular events, such as transcription, replication and DNA repair. To control these processes, the architecture of the DNA is tightly regulated. Recent work, including two studies in this issue of The EMBO Journal , provides compelling evidence that cohesin structures chromosomes through the processive enlargement of loops. While cohesin promotes chromosomal looping, it rather counteracts nuclear compartmentalization.