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Colonic epithelium rejuvenation through YAP / TAZ
Author(s) -
Chen Rui,
Guan KunLiang
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201798618
Subject(s) - biology , rejuvenation , microbiology and biotechnology , epithelium , genetics
Stem cells are critical for normal tissue homeostasis and injury‐induced regeneration, but how wounding affects tissue regeneration at the cellular and molecular levels is not yet fully understood. A new study by Yui et al ([Yui S, 2018]) demonstrates that the extracellular matrix ( ECM ) remodeling modulates intestinal stem cells in tissue repair and regeneration via activation of the Hippo pathway effectors YAP / TAZ .
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