Premium
Shoring up DNA methylation and H3K27me3 domain demarcation at developmental genes
Author(s) -
Meehan Richard R,
Pennings Sari
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201798498
Subject(s) - dna methylation , epigenetics , biology , genetics , library science , gene , gene expression , computer science
Mutual antagonism between DNA methylation and H3K27me3 histone methylation suggests a dynamic crosstalk between these epigenetic marks that could help ensure correct gene expression programmes. Work from Manzo et al ([Manzo M, 2017]) now shows that an isoform of de novo DNA methyltransferase DNMT 3A provides specificity in the system by depositing DNA methylation at adjacent “shores” of hypomethylated bivalent CpG islands (CGI) in mouse embryonic stem cells ( mESC s). DNMT 3A1‐directed methylation appears to be instructive in maintaining the H3K27me3 profile at the hypomethylated bivalent CGI promoters of developmentally important genes.