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A genetically distinct microglial subset promotes myelination
Author(s) -
Bennett Mariko L,
Barres Ben A
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201798389
Subject(s) - microglia , biology , myelinogenesis , cd11c , neuroscience , neuroinflammation , immunology , myelin , central nervous system , genetics , oligodendrocyte , gene , inflammation , phenotype
Microglia are brain‐resident macrophages with important, but insufficiently understood functions in development, health, and disease. In a new exciting study, Wlodarczyk and colleagues uncover a transient subset of CD11c + microglia that regulate CNS myelination via IGF‐1 expression. These findings represent not only the first evidence for a microglial role in myelinogenesis, but the first for a functionally distinct, genetically defined subpopulation of microglia.