A genetically distinct microglial subset promotes myelination | Zendy

Bennett Mariko L | Zendy; Barres Ben A | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A genetically distinct microglial subset promotes myelination

Author(s) -

Bennett Mariko L,

Barres Ben A

Publication year - 2017

Publication title -

the embo journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.484

H-Index - 392

eISSN - 1460-2075

pISSN - 0261-4189

DOI - 10.15252/embj.201798389

Subject(s) - microglia , biology , myelinogenesis , cd11c , neuroscience , neuroinflammation , immunology , myelin , central nervous system , genetics , oligodendrocyte , gene , inflammation , phenotype

Microglia are brain‐resident macrophages with important, but insufficiently understood functions in development, health, and disease. In a new exciting study, Wlodarczyk and colleagues uncover a transient subset of CD11c + microglia that regulate CNS myelination via IGF‐1 expression. These findings represent not only the first evidence for a microglial role in myelinogenesis, but the first for a functionally distinct, genetically defined subpopulation of microglia.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research