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Initiating meiosis in a dish
Author(s) -
Gill Mark E,
Peters Antoine HFM
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201798101
Subject(s) - biology , meiosis , genetics , microbiology and biotechnology , gene
Embryonic germ cells are formed from embryonic progenitors through a highly complex differentiation process, recapitulation of which in vitro has proved challenging. Two new studies in The EMBO Journal report culture conditions for embryonic stem cell‐derived primordial germ cell‐like cells ( PGCLC s) that enable global DNA demethylation (Ohta et al , [Ohta H, 2017]), and subsequent initiation of meiosis (Miyauchi et al , [Miyauchi H, 2017]), allowing future manipulations to elucidate mechanisms driving germ line differentiation.