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Chromosome structure dynamics during the cell cycle: a structure to fit every phase
Author(s) -
Barrington Christopher,
Pezic Dubravka,
Hadjur Suzana
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201798014
Subject(s) - biology , cell cycle , cell cycle progression , cell division , microbiology and biotechnology , chromosome , genetics , cell cycle protein , computational biology , cell , genome , gene
Chromosomes undergo dramatic morphological changes as cells advance through the cell cycle. Using powerful molecular and computational methods, several recent studies revealed an outstanding complexity of continuous structural changes accompanying cell cycle progression. In agreement with cell division being a fundamental cellular process, characteristic features of cell cycle stage‐specific genome structure are conserved from yeast to mouse. These studies further shine light on the critical roles that SMC complexes, already well known as fundamental regulators of chromosome topology, have in orchestrating structural dynamics throughout the cell cycle.