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RNA polymerase I, bending the rules?
Author(s) -
Jochem Laura,
Ramsay Ewan P,
Vannini Alessandro
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201797924
Subject(s) - rna polymerase ii , transcription (linguistics) , transcription factor ii d , transcription factor ii f , rna polymerase iii , general transcription factor , biology , rna , rna polymerase ii holoenzyme , genetics , transcription factor ii e , polymerase , rna polymerase , computational biology , dna , microbiology and biotechnology , gene , gene expression , promoter , linguistics , philosophy
Transcription initiation is one of the key regulatory steps in expressing the genetic information encoded in the DNA . Mechanisms of RNA Pol II transcription have been extensively studied, whereas the structural basis of RNA Pol I and III transcription is still poorly defined. Three recent studies discussed here give a first glimpse into the molecular mechanisms underlying the process of RNA Pol I transcriptional initiation and reveal unexpected structural differences compared to the previously described homologous Pol II structures.