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Live and let die: ZBP1 senses viral and cellular RNAs to trigger necroptosis
Author(s) -
Assil Sonia,
Paludan Søren R
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201797845
Subject(s) - necroptosis , biomedicine , biology , virology , programmed cell death , bioinformatics , genetics , apoptosis
Necroptosis is a programmed form of inflammatory cell death involved in various pathologies, such as viral infections. In two new papers published in The EMBO Journal and EMBO Reports , Z‐DNA binding protein 1 (ZBP1) is now shown to sense RNAs during viral infection or after caspase inhibition and activate necroptosis. This may suggest that Z‐RNAs are molecular patterns for activation of necroptosis.