A forceful connection: mechanoregulation of oncogenic YAP | Zendy

Böttcher Ralph Thomas | Zendy; Sun Zhiqi | Zendy; Fässler Reinhard | Zendy

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A forceful connection: mechanoregulation of oncogenic YAP

Author(s) -

Böttcher Ralph Thomas,

Sun Zhiqi,

Fässler Reinhard

Publication year - 2017

Publication title -

the embo journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.484

H-Index - 392

eISSN - 1460-2075

pISSN - 0261-4189

DOI - 10.15252/embj.201797527

Subject(s) - german , alliance , library science , center (category theory) , physics , chemistry , political science , history , law , computer science , archaeology , crystallography

The Yes‐associated protein ( YAP ) is an important transcriptional co‐activator that mediates the cellular response to mechanical and cytoskeletal cues. In two recent papers published in The EMBO Journal , Dae‐Sik Lim and colleagues show how YAP activity affects cancer formation and metastasis via a crosstalk with myocardin‐related transcription factors (MRTFs; Kim et al , 2017) and SKP2‐dependent cell cycle progression (Jang et al , 2017).

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