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A forceful connection: mechanoregulation of oncogenic YAP
Author(s) -
Böttcher Ralph Thomas,
Sun Zhiqi,
Fässler Reinhard
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201797527
Subject(s) - german , alliance , library science , center (category theory) , physics , chemistry , political science , history , law , computer science , archaeology , crystallography
The Yes‐associated protein ( YAP ) is an important transcriptional co‐activator that mediates the cellular response to mechanical and cytoskeletal cues. In two recent papers published in The EMBO Journal , Dae‐Sik Lim and colleagues show how YAP activity affects cancer formation and metastasis via a crosstalk with myocardin‐related transcription factors (MRTFs; Kim et al , 2017) and SKP2‐dependent cell cycle progression (Jang et al , 2017).