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A new twist to Sin3 complexes in pluripotent cells
Author(s) -
Pantier Raphaël,
Mullin Nicholas P,
Chambers Ian
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201797516
Subject(s) - biology , embryonic stem cell , microbiology and biotechnology , induced pluripotent stem cell , cell cycle , function (biology) , histone deacetylase , histone , cell , genetics , gene
Sin3a is a central component of a class of histone deacetylase‐containing transcriptional co‐regulatory complexes. In this issue of The EMBO Journal , Streubel et al ([Streubel G, 2017]) purify Sin3a and identify a variant Sin3a complex containing Fam60a in undifferentiated embryonic stem cells ( ESC s). Fam60a is a critical component of the ESC Sin3a complex since Fam60a knockdown leads to an extended G1 cell cycle phase and reduced ESC self‐renewal. These exciting results open up new questions about how biochemical differences between variant Sin3a complexes may facilitate alterations in cell‐specific function.