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Suppressing mTORC1 on the lysosome
Author(s) -
Raiborg Camilla,
Schink Kay O,
Stenmark Harald
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201797469
Subject(s) - mtorc1 , pi3k/akt/mtor pathway , biology , mtorc2 , mechanistic target of rapamycin , lysosome , activator (genetics) , microbiology and biotechnology , rptor , protein subunit , kinase , signal transduction , biochemistry , enzyme , gene
The mechanistic target of rapamycin, mTOR, is a protein kinase that integrates environmental and nutritional inputs into regulation of cell growth and metabolism. Key outputs of mTOR signalling occur from the lysosome membrane in the form of the multi‐subunit mTOR complex 1 (mTORC1), which phosphorylates multiple targets. While class I phosphoinositide kinase (PI3K‐I) is a well‐known activator of mTORC1, a recent paper (Marat et al , 2017) shows that a class II PI3K with a different substrate specificity, PI3K‐C2β, serves to inhibit mTORC1 on lysosomes under conditions of growth factor deprivation.