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NIX ‐ing mitochondria: from development to pathology
Author(s) -
Deczkowska Aleksandra,
Schwartz Michal
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201797110
Subject(s) - context (archaeology) , library science , mitophagy , biology , editorial board , neuroscience , computer science , genetics , paleontology , apoptosis , autophagy
Hypoxia occurs physiologically in the developing body, and changing oxygen tensions are known to direct tissue differentiation; however, in the context of pathology, the same hypoxia‐activated mechanisms may negatively affect tissue function. In this issue of The EMBO Journal , Esteban‐Martínez et al (2017) report that programmed mitophagy, dependent on hypoxia‐induced NIP ‐3‐like protein X ( BNIP 3L, best known as NIX ), is an essential step in differentiation of both retinal neurons and inflammatory macrophages.