Premium
TRAIL ‐ and TNF ‐induced signaling complexes—so similar yet so different
Author(s) -
Wajant Harald
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201796997
Subject(s) - biology , receptor , signal transduction , cytosol , microbiology and biotechnology , tumor necrosis factor alpha , cytotoxic t cell , programmed cell death , apoptosis , immunology , biochemistry , enzyme , in vitro
TNF receptor‐1 ( TNFR 1) and TRAIL death receptors preferentially induce pro‐inflammatory or cytotoxic signaling, respectively, via distinct plasma membrane and cytosolic complexes. New studies identifying the pro‐inflammatory factors TRAF 2, RIP , and LUBAC in TRAIL death receptor complexes suggest that the latter are more “ TNFR 1‐like” than anticipated and argue for revision of prevailing models of spatio‐hierarchical TRAIL ‐induced signaling complex assembly.