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Re‐evaluating the foundations of lnc RNA –Polycomb function
Author(s) -
Blanco Mario R,
Guttman Mitchell
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201796796
Subject(s) - hotair , biology , rna , gene silencing , regulation of gene expression , non coding rna , rna binding protein , gene expression , long non coding rna , function (biology) , prc2 , gene , microbiology and biotechnology , genetics , computational biology , ezh2
Many lnc RNA s are thought to interact with the polycomb repressive complex 2 ( PRC 2) in order to regulate gene expression. A central example of this lnc RNA – PRC 2 paradigm in gene regulation is HOTAIR . In this issue of The EMBO Journal, a study (Portoso et al, [Portoso M, 2017]) reports that while HOTAIR binds PRC 2 with high affinity, the complex itself is dispensable for HOTAIR ‐mediated transcriptional silencing. This study raises important questions about the role of PRC 2 interactions for lnc RNA ‐mediated functions and argues for a re‐evaluation of this lnc RNA – PRC 2 functional paradigm.