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Judging a tumor cell by its cover: a matter of mitochondrial contact sites
Author(s) -
Lakshminarayanan Sowmya,
Scorrano Luca
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201796637
Subject(s) - biology , cytotoxic t cell , mitochondrion , immune system , endoplasmic reticulum , glioblastoma , glioma , microbiology and biotechnology , cell , cancer research , immunology , genetics , in vitro
Glioblastoma is a highly aggressive brain tumor constituted by glioma stem cell and differentiated cell populations with distinct susceptibility to cytotoxic T lymphocytes crucial for tumor immune surveillance. In this issue of The EMBO Journal , Bassoy et al ([Bassoy EY, 2017]) show that the surface expression of certain glycans that favor recognition and killing by T cells depends on mitochondrial contacts with the endoplasmic reticulum, extending the function of this interface even to immune recognition.