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Written in bone: young bone makes young blood
Author(s) -
Gustafsson Karin,
Scadden David T
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201796634
Subject(s) - stem cell , regenerative medicine , stem cell biology , biology , library science , gerontology , medicine , computer science , genetics , embryo , reproductive technology , embryogenesis
Ageing of bone marrow haematopoietic stem cells has been mostly associated with cell‐intrinsic mechanisms. New findings published in The EMBO Journal now show that reduced levels of the secreted matrix protein osteopontin in old bone marrow stroma cause ageing‐associated features in HSC s. In line, old HSC s are functionally rejuvenated by interaction with protease‐cleaved osteopontin fragment, and perform like young blood stem cells in vivo .