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The p53‐inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation
Author(s) -
Khan Muhammad Riaz,
Xiang Shaoxun,
Song Zhiyin,
Wu Mian
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201696239
Subject(s) - biology , starvation , rna , necrosis , long non coding rna , microbiology and biotechnology , biochemistry , cancer research , genetics , gene , endocrinology
Abstract The tumor suppressor p53 is activated in response to cellular stress to prevent malignant transformation. However, several recent studies have shown that p53 can play protective roles in tumor cell survival under adversity. Whether p53‐regulated long noncoding RNA s are involved in this process remains to be fully understood. Here, we show that under glucose starvation condition, p53 directly upregulates a novel lnc RNA named TRINGS (Tp53‐regulated inhibitor of necrosis under glucose starvation) in human tumor cells. TRINGS binds to STRAP and inhibits STRAP – GSK 3β– NF ‐κB necrotic signaling to protect tumor cells from cell death. Interestingly, TRINGS appears to respond to glucose starvation specifically, as it is not activated by serum, serine, or glutamine deprivation. Collectively, our findings reveal that p53‐induced lnc RNA TRINGS controls the necrotic pathway and contributes to the survival of cancer cells harboring wild‐type p53 under glucose stress.