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TFIID or not TFIID , a continuing transcriptional SAGA
Author(s) -
Kubik Slawomir,
Bruzzone Maria Jessica,
Shore David
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201696152
Subject(s) - biology , taf1 , transcription factor ii d , genetics , gene , rna polymerase ii , tata box , housekeeping gene , microbiology and biotechnology , gene expression , promoter
Eukaryotic protein‐coding genes are typically classified into two groups: those with expression regulated by specific signals versus the relatively constant “housekeeping” genes. Although these differences are associated with alternative modes of RNA polymerase II ( RNAP II ) pre‐initiation complex ( PIC ) assembly, a role for gene‐specific activators in controlling “regulatability” has been difficult to rule out. To address this question, de Jonge et al ([de Jonge WJ, 2017]) studied a group of genes controlled by a common activator but dependent on either TFIID or SAGA and found that the magnitude of regulation strongly correlates with the mechanism of PIC assembly.