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Endothelial cell metabolism in health and disease: impact of hypoxia
Author(s) -
Wong Brian W,
Marsch Elke,
Treps Lucas,
Baes Myriam,
Carmeliet Peter
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201696150
Subject(s) - angiogenesis , biology , hypoxia (environmental) , crosstalk , disease , hypoxia inducible factors , metabolism , cancer research , endothelial stem cell , cell metabolism , cell , hif1a , bioinformatics , microbiology and biotechnology , medicine , endocrinology , biochemistry , chemistry , organic chemistry , oxygen , physics , gene , optics , in vitro
In contrast to the general belief, endothelial cell ( EC ) metabolism has recently been identified as a driver rather than a bystander effect of angiogenesis in health and disease. Indeed, different EC subtypes present with distinct metabolic properties, which determine their function in angiogenesis upon growth factor stimulation. One of the main stimulators of angiogenesis is hypoxia, frequently observed in disease settings such as cancer and atherosclerosis. It has long been established that hypoxic signalling and metabolism changes are highly interlinked. In this review, we will provide an overview of the literature and recent findings on hypoxia‐driven EC function and metabolism in health and disease. We summarize evidence on metabolic crosstalk between different hypoxic cell types with EC s and suggest new metabolic targets.