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Nutrient sensing and TOR signaling in yeast and mammals
Author(s) -
González Asier,
Hall Michael N
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201696010
Subject(s) - biology , nutrient sensing , tor signaling , yeast , pi3k/akt/mtor pathway , nutrient , saccharomyces cerevisiae , microbiology and biotechnology , cell growth , mechanistic target of rapamycin , cell , signal transduction , genetics , computational biology , ecology
Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in particular amino acids. As a central controller of cell growth, mTOR (mammalian TOR ) is implicated in several disorders, including cancer, obesity, and diabetes. Here, we review how nutrient availability is sensed and transduced to TOR in budding yeast and mammals. A better understanding of how nutrient availability is transduced to TOR may allow novel strategies in the treatment for mTOR ‐related diseases.