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Zika virus NS 1, a pathogenicity factor with many faces
Author(s) -
Hilgenfeld Rolf
Publication year - 2016
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201695871
Subject(s) - biology , zika virus , pathogenicity , virology , virus , flavivirus , structural protein , computational biology , microbiology and biotechnology
Recent publications in The EMBO Journal (Xu et al , [Xu X, 2016]) and in Nature Structural & Molecular Biology (Brown et al , [Brown WC, 2016]) report crystal structures of the Zika virus ( ZIKV ) NS 1 protein. The structures reveal unique surface properties that help explain the specificity of anti‐ ZIKV NS 1 antibodies. Possible functions of this multifaceted pathogenicity factor are discussed here on the basis of the structures and cautious extrapolation from other flaviviruses.