Premium
Too much to differentiate: aneuploidy promotes proliferation and teratoma formation in embryonic stem cells
Author(s) -
Storchová Zuzana
Publication year - 2016
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201695486
Subject(s) - aneuploidy , embryonic stem cell , biology , genome , stem cell , genome instability , ploidy , genetics , chromosome , computational biology , microbiology and biotechnology , dna , dna damage , gene
Aneuploidy, or an uneven number of chromosomes, has mostly detrimental consequences in eukaryotic cells, which include impaired proliferation as well as compromised DNA replication and protein folding. Unexpectedly, a new study published in this issue of The EMBO Journal shows that in murine embryonic stem cells aneuploidy does not interfere with proliferation, but rather hinders their differentiation capacity, thus propelling the formation of poorly differentiated teratomas.