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A plant solution to the CDK conundrum in the DNA damage response
Author(s) -
Desvoyes Bénédicte,
Gutierrez Crisanto
Publication year - 2016
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201695348
Subject(s) - biology , cyclin dependent kinase , homologous recombination , cell cycle , microbiology and biotechnology , dna , dna damage , genetics , gene
To cope with DNA damage, proliferating cells have evolved sophisticated mechanisms including cell cycle arrest and activation of DNA repair. Paradoxically, various DNA damage response pathways are promoted by cyclin‐dependent kinase ( CDK ) activity, while cell cycle remains arrested. New work in The EMBO Journal shows that plant cells have evolved intricate ways to resolve this dilemma, by utilizing distinct and specialized CDK s for cell cycle progression and homologous recombination.