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Type I interferon is required for T helper (Th) 2 induction by dendritic cells
Author(s) -
Webb Lauren M,
Lundie Rachel J,
Borger Jessica G,
Brown Sheila L,
Connor Lisa M,
Cartwright Adam NR,
Dougall Annette M,
Wilbers Ruud HP,
Cook Peter C,
JacksonJones Lucy H,
PhythianAdams Alexander T,
Johansson Cecilia,
Davis Daniel M,
Dewals Benjamin G,
Ronchese Franca,
MacDonald Andrew S
Publication year - 2017
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201695345
Subject(s) - biology , interferon , interferon type i , virology , microbiology and biotechnology
Type 2 inflammation is a defining feature of infection with parasitic worms (helminths), as well as being responsible for widespread suffering in allergies. However, the precise mechanisms involved in T helper (Th) 2 polarization by dendritic cells ( DC s) are currently unclear. We have identified a previously unrecognized role for type I IFN ( IFN ‐I) in enabling this process. An IFN ‐I signature was evident in DC s responding to the helminth Schistosoma mansoni or the allergen house dust mite ( HDM ). Further, IFN ‐I signaling was required for optimal DC phenotypic activation in response to helminth antigen (Ag), and efficient migration to, and localization with, T cells in the draining lymph node ( dLN ). Importantly, DC s generated from Ifnar1 −/− mice were incapable of initiating Th2 responses in vivo . These data demonstrate for the first time that the influence of IFN ‐I is not limited to antiviral or bacterial settings but also has a central role to play in DC initiation of Th2 responses.