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A code within a code: how codons influence mRNA stability
Author(s) -
Martinez Javier,
Zagrovic Bojan
Publication year - 2016
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201695283
Subject(s) - biology , code (set theory) , messenger rna , genetic code , genetics , computational biology , gene , programming language , computer science , set (abstract data type)
The genetic code was deciphered more than 50 years ago, but we are only now becoming aware of a second, hidden code. It is the concept of “codon optimality” that enters the scene of developmental and homeostatic gene expression, linking translation rates, mRNA stability, and tRNA abundance. Both at the biological and methodological levels, work by Giraldez and colleagues in this issue of The EMBO Journal paves the way for further analyses of such key regulatory mechanisms.