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Mitochondrial DNA mutations in iPS cells: mt DNA integrity as standard iPSC selection criteria?
Author(s) -
Hämäläinen Riikka H
Publication year - 2016
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201695185
Subject(s) - biology , heteroplasmy , somatic cell , mitochondrial dna , mutation , dna , microbiology and biotechnology , genetics , gene
Somatic cells harbor random heteroplasmic mitochondrial DNA mutations, which are considered to contribute to aging. In this issue of The EMBO Journal , Perales‐Clemente et al ([Perales‐Clemente E, 2016]) show that mt DNA mutations, present at low levels in the starting fibroblasts, become enriched in iPS cells and lead to functional defects in iPS ‐derived cells. In another recent study, Kang et al ([Kang E, 2016]) demonstrated that accumulation of mt DNA mutations of somatic origin in iPSC s is age related.