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Autophagosome–lysosome fusion: PI s to the rescue
Author(s) -
Li Linsen,
Zhong Qing
Publication year - 2016
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201695134
Subject(s) - biology , lysosome , pi , microbiology and biotechnology , lipid bilayer fusion , virology , biochemistry , membrane , enzyme
Phosphoinositides ( PI s), a small fraction of the cellular lipids, function in almost all cellular physiological processes and especially in intracellular membrane trafficking events. PI s play a critical role in autophagy, but only PI (3)P is well studied. In this issue of The EMBO Journal , Hasegawa et al (2016) identified INPP 5E, an inositol polyphosphate 5‐phosphatase, as a novel regulator of autophagy. INPP 5E controls the level of PI (3,5)P 2 at the lysosome and thereby locally regulates the actin cytoskeleton and autophagosome–lysosome fusion.