FUS cinating insights into motor neuron degeneration | Zendy

Dormann Dorothee | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

FUS cinating insights into motor neuron degeneration

Author(s) -

Dormann Dorothee

Publication year - 2016

Publication title -

the embo journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.484

H-Index - 392

eISSN - 1460-2075

pISSN - 0261-4189

DOI - 10.15252/embj.201694397

Subject(s) - amyotrophic lateral sclerosis , biology , degeneration (medical) , motor neuron , neuroscience , gain of function , loss function , mutant , neuron , neuronal degeneration , function (biology) , motor function , neurodegeneration , mechanism (biology) , disease , microbiology and biotechnology , genetics , phenotype , pathology , gene , physical medicine and rehabilitation , medicine , spinal cord , epistemology , philosophy

Point mutations in FUS cause amyotrophic lateral sclerosis ( ALS ), a devastating neurodegenerative disease—but do they do that by a loss of the protein's normal function, or by endowing it with novel toxic functions, or both? In this issue of The EMBO Journal , Scekic‐Zahirovic et al ([Scekic‐Zahirovic J, 2016]) report that mutant FUS , but not the complete loss of FUS , triggers motor neuron degeneration in mice, arguing for a toxic gain‐of‐function mechanism.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research