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eIF 4A moonlights as an off switch for TORC1
Author(s) -
Swierczynska Marta M,
Hall Michael N
Publication year - 2016
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201694326
Subject(s) - biology , translation (biology) , amino acid , mechanism (biology) , biochemistry , microbiology and biotechnology , messenger rna , gene , philosophy , epistemology
TORC 1 is actively inhibited upon amino acid withdrawal. Tsokanos et al ([Tsokanos FF, 2016]) shed light on the underlying molecular mechanism. They demonstrate that upon removal of exogenous amino acids, eIF 4A inhibits TORC 1 via TSC 2. Thus, whereas it is well known that TORC 1 regulates the translation machinery, we now know the inverse is also true.