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cGAS ‐ STING do it again: pivotal role in RN ase H2 genetic disease
Author(s) -
Gentili Matteo,
Manel Nicolas
Publication year - 2016
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201694226
Subject(s) - biology , sting , disease , gene , genetics , microbiology and biotechnology , immunology , medicine , pathology , engineering , aerospace engineering
RN ase H2 is a susceptibility gene for the Aicardi–Goutières syndrome ( AGS ), a genetic auto‐inflammatory disease. Mackenzie and colleagues now report a tractable mouse model for the disease, implicating the cGAS ‐ STING pathway.
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