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Mitochondria and senescence: new actors for an old play
Author(s) -
Herranz Nicolás,
Gil Jesús
Publication year - 2016
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201694025
Subject(s) - senescence , mitochondrion , biology , ageing , microbiology and biotechnology , mitochondrial biogenesis , biogenesis , cellular senescence , autophagy , phenotype , genetics , apoptosis , gene
Mitochondrial dysfunction has been linked to both cellular senescence and ageing. Despite the relationship, it is still unclear whether mitochondria have a causal role in senescence. In this issue of The EMBO Journal , Correia‐Melo et al ([Correia‐Melo C, 2016]) combine targeted depletion of mitochondria with impairment of their biogenesis to demonstrate that decreased numbers of mitochondria impair the senescence response. Their results suggest that targeting mitochondria could reduce the detrimental effects of senescence during ageing.