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The cis ‐regulatory switchboard of pancreatic ductal cancer
Author(s) -
Ferrer Jorge,
Real Francisco X
Publication year - 2016
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.15252/embj.201693999
Subject(s) - biology , pancreatic cancer , cancer , cancer research , computational biology , medicine , genetics
Pancreatic ductal adenocarcinoma ( PDAC ) remains one of the most devastating human diseases. There is consequently a pressing need to understand its molecular underpinnings, which should enable new preventive and therapeutic strategies. A new study in The EMBO Journal (Diaferia et al , 2016) maps the transcriptome and epigenetic landscape associated with distinct PDAC grades and identifies cis ‐ and trans ‐regulatory elements in tumour progression.
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